Endocrine Abstracts

Recent studies in various species have pointed out that Neurokinin B (NKB), encoded by Tac2 in rodents, and its receptor, NK3R, are important regulators of reproduction. NKB is co-expressed in Kiss1 neurons of the arcuate nucleus (ARC) and stimulates, via auto-regulatory loops, kisspeptin output onto GnRH neurons, therefore stimulating gonadotropin secretion. However, important aspects of the roles of NKB as regulators of the gonadotropic axis remain unknown. We report here th...